Portable, easy-to-use centrifugal concentration/evaporation system provides safe, rapid drying of purified fractions and lab scale reaction mixtures. Operators simply load samples, set the temperature, and close the lid to start the rotor – no complex programming is required. The system is available with an optional off-timer that enables operators to stop the evaporation process before samples reach complete dryness. System is suitable for drying medicinal chemistry scaffold modifications in drug discovery as well as the reaction mixtures of many other synthetic chemistry applications. The compact unit is also very effective for sample prep evaporation steps and for drying purified lab scale fractions from a Flash LC or HPLC.