Researchers in cellular, tissue, developmental and neurobiology, as well as toxicology and pharmacology, need to see nanoscale detail over relatively large sample volumes in order to understand functions and interactions within cells and tissues. The Teneo VS scanning electron microscope (SEM) is designed to deliver excellent resolution over large volumes and allows life scientists to explore the structure and interactions of cells and tissues down to the nanometer scale. The platform is integrated with an in-chamber microtome and analytical software that enables fully automated, large-volume reconstructions with dramatically improved z-axis resolution. Tight integration and extensive automation ensures fast, easy analysis. FEI
Image description: Volume reconstruction of mouse brain acquired with Teneo VS™. The block-face was imaged with the combination of Serial Block Face SEM and Multi-Energy Deconvolution SEM. 3D data visualization and reconstruction was done with Amira. Model depicting several axons (blue, purple and green). Isotropic pixels of 10 x 10 x 10 nm (x,y,z); Reconstructed volume 15.00 um x 12.9 um x 10.4 µm (1040 slices). Sample courtesy of P. Laserstein & P. Bastians, Helmstaedter Lab, MPI Frankfurt, Germany.
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