A new guide details top 10 tips for ChIP-seq library preparation. ChIP-sequencing, also known as ChIP-seq, is a method used primarily to determine how transcription factors and other chromatin-associated proteins influence phenotype-affecting mechanisms.
Determining how proteins interact with DNA to regulate gene expression is essential for fully understanding many biological processes and disease states. ChIP-seq combines chromatin immunoprecipitation (ChIP) with massively parallel DNA sequencing to identify the binding sites of DNA-associated proteins.
High-quality library preparation is key to a successful ChIP-seq experiment. Written by scientists with many years’ experience of ChIP assay development, the new document provides an informative 10-point illustrated guide to help improve ChIP-seq library preparation.
A pdf version of the guide can be downloaded here. Chromatrap, part of Porvair Sciences Ltd.
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