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Concentrator helps sports drug testing lab accelerate sample preparation


A new applications report details how the manufacturer’s sample concentrator has been used by a testing laboratory to develop a new sample preparation method to help curb sports doping.

 

Recent developments in applying mass spectrometry to proteomics means that it is becoming feasible for doping laboratories to routinely detect and confirm the abuse of peptide hormones by sportsmen and women. Using mass spectrometry to detect and confirm the abuse of peptide hormones is preferred to the use of immunoassay techniques as the methodology is able to positively differentiate between endogenous insulin and its synthetic analogues. To use LC-MS techniques to detect synthetic insulin however requires that samples are extracted and concentrated prior to analysis. This traditionally time consuming procedure requires at least one evaporation of a solution with high water content.

 

Using the sample concentrator, the Australian Sports Drug Testing Lab was able to significantly improve their sample preparation method for synthetic insulin’s in serum.  Sample preparation times were reduced from several days to just 2 hours and better and more consistent recoveries were obtained than using the traditional nitrogen blow down evaporation method.

 

The affordably priced concentrator provides careful and speedy biological sample concentration and drying from a variety of sample formats including tubes, microplates and vials. The compact unit features built-in special methods for working with alcohols, water and water mixtures to improve performance and optimize concentration times.

 Genevac


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