Suitable for the extraction of DNA, RNA, protein, mitochondria, and small molecules, the PBI Shredder SG3 creates a closed system in which to safely prepare samples. Portable for easy and efficient field collection, the system operates by using pressure, which forces the sample against the lysis plate in the tubes for low-shear cell disruption. The resulting samples exceed the yields of those derived from traditional labor-intensive methods such as manual mortar and pestle preparation. The samples also offer better integrity than bead beating methods. Higher reproducibility and lower cost in sample preparation make this device suitable for research labs, forensics, cryogenics, medical diagnostics, and more. It also offers full chain-of-custody tracking from collection to testing.