Lab Canada

Stem cells may prevent and cure Alzheimer’s

Seoul, South Korea – Researchers at Korea’s Seoul National University and the RNL Stem Cell Technology Institute announced this week the results of a study that suggests that adult stem cells may not only have a positive effect on those suffering from Alzheimer’s disease, they can prevent the disease. Using fat-derived adult stem cells from humans, adMSCs (human, adipose-derived mesenchymal stem cells), researchers were able to cause Alzheimer’s disease brains in animal models to regenerate. The researchers used stem cells to identify the mechanism that is key to treatment of Alzheimer’s disease, and demonstrated how to achieve efficacy as well as prevention of the symptoms of Alzheimer’s with adult stem cells.

This study was published in a recent volume of the journal PLOS ONE.

The study was jointly led by Seoul National University Professor Yoo-Hun Suh and RNL Bio Stem Cell Technology Institute (SCTI) director Dr. Jeong-Chan Ra.

The researchers and their teams injected stem cells into mice genetically designed to have the core symptoms and physiology of Alzheimer’s disease. They were able to identify that these human stem cells, derived from adipose tissue, behave in a very special way when injected into the tail vein of mice subjects. The cells migrated through the blood brain barrier, thought by many to be impossible for adult stem cells to cross, and went into the brain. In fact, fluorescent labeled cells were monitored for distribution in subjects and the team identified that the infused cells migrated throughout the bodies including brain except the olfactory organ, and therefore confirmed that IV infused stem cell can reach to the brain across the blood brain barrier.

The team infused human adipose stem cells intravenously in Alzheimer model mice multiple times two weeks apart from three month to 10 month. Once there, the mice who received cells improved in every relevant way: ability to learn, ability to remember, and neuropathological signs. More important, for the first time ever, Alzheimer model mice showed the mediation of IL-10, which is known for anti-inflammation and neurological protection.